Tramadol is a unique compound with moderate mu-opioid activity (compared to traditional opioids) and moderate monoaminergic activity (compared to tricyclic antidepressants). Tramadol has a more acceptable side effect profile than tricyclic antidepressants and antiepileptic drugs. Although possible, tolerance and dependence are rare complications of treatment. Of the four main types of pain, the effect of tramadol is not limited to neuropathic pain, but also includes suppression of noxious (nociceptive) pain.
Classification of types of pain treated with tramadol
Neuropathic pain occurs spontaneously or periodically from damaged nerves. The nerve signals behind neuropathic pain are different from the signals transmitted along healthy nerves from damaged tissue (which can occur as a result of a fall, cut, or burn). This type of pain requires special medications known as painkillers; not uncommon as a result of spinal cord injury, Buy Tramadol Online amputated limbs (phantom pain), and postherpetic conditions.
Opioid pain relievers such as tramadol and morphine are often useful in neuropathic cases. The drugs above work equally effectively for nociceptive pain, which is the normal response of an organ/tissue to an adverse injury. The latter type includes cases of musculoskeletal and visceral pain. Sometimes a dangerous source of pain can be localized (eg joint pain or skin injury); in other cases, the pain may be related to internal organs or tissues.
