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Clindamycin is a topical antibiotic skin gel used treat acne that has become infected and is unresponsive to non-antibiotic treatment. Clindac-A gets into the blackheads (comedones) that form on the skin and kills the bacteria that infect acne affected skin.Clindamycin can cause diarrhea, which may be severe or lead to serious, life-threatening intestinal problems. Clindamycin is an antibiotic that fights bacteria in the body.