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Most Detox Sacrifice Your Metabolic Rate, take note most detox approaches - any approach that has you eating fewer than 1000 calories per day - is going to destroy your metabolic rate. Sure, you might lose some weight when you first begin but after you come off the detox cleanse, you'll be gaining it right back again.Reasons to Avoid That Detox Cleanse - A Cleanse Can Destroy Good Nutrition. Take note many detox plans can destroy good nutrition. They have you eating nothing but vegetables for a week straight, letting you think this is healthy.