Accurate Dosing is Essential inAtomization
Since then there have been manynew devices being introduced in the NasalAtomizer Devices Market with improving dosage accuracy. Accurate dosing isessential in a nasal atomization device to circumvent any side effects due tooverdose. Recently in November 2016, Teleflex Medical Corporation recalled itsMAD Nasal Intranasal Mucosal atomization device which contained drug to reversethe action of opioid overdose. The device was recalled on the warning that itmay not deliver the proper dose of the drug naloxone hydrochloride. This drugwith the device is extensively used by the policemen and firefighters in theU.S.
The market still in its nascentstages of adoption is experiencing increasing acceptance in the developedregions of North America and Europe. However, creating awareness among thehealthcare professionals and patients is essential for acceptance of this noveltechnology. Increasing self-medication trend can be leveraged upon forpenetrating the global nasal drug delivery devices market.
Major market players includeDeVilbiss Healthcare, Teleflex Incorporated, and Kurve Technology, etc. Being aniche segment of drug delivery, there exists a lot potential for manufacturersof nasal drug delivery systems.
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Nasal delivery is a choice oftreatment or drug delivery for the topical treatment of nasal diseases andparanasal sinuses like sinusitis and allergic rhinitis. Moreover, the nasalroute is considered in some cases over the normal oral route owing to rapidabsorption and needle-free drug delivery with the effect as desired. Hence, itis also one of the preferred routes for needle-free vaccination and systemicdrug delivery. Moreover, this route helps addressing issues related to poorbioavailability, slow absorption, drug degradation and adverse events in thegastrointestinal tract. Atomized nasal medications rapidly absorb acrossmucosal membranes into the bloodstream, avoiding first-pass metabolism.However, during nasal delivery one needs to take care to protect the delicatelungs from hazardous exposures. Medication in liquid form can be administeredvia nasal route through inhalers, spray pumps, droppers, nebulizers oratomizers. In atomizers the medication exits the tip as a fine atomized mistresulting in broad coverage of the nasal mucosal with a thin layer of drug.
Nasal Atomizer Device Types
Nasal atomizers are currentlyused in the treatment of allergic rhinitis and sinusitis. These devices usuallyare multi-dose products enabling long-term usage of the device. The nasalatomizers are classified based on the technology/mechanics as gas propelled orelectrical. The air or gas controlled technique involves the use of squeezedbottle which when pressed releases the content out of the small nozzle indefinite volume. The dose delivered however is highly dependent on the pressureapplied while squeezing the bottle. An electronic atomizer on the other hand isdevised to release only a defined amount of medication from the nozzle. Thismakes the use of device more convenient for patients at home.
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Kurve Technology had designed anddeveloped a nasal drug delivery device called ViaNase in 2004 that used acontrolled particle dispersion method. During that period, Kurve’s technologywas the only known technique that delivered chemical formulations via the noseto the paranasal sinuses in clinical testing. Moreover, Kurve’s technology wasalso designed to be used with multiple drugs.
Key Developments
Increasing availability of drugin the form of a nasal atomizer is expected to boost the market growth. Forinstance, Naloxone, a drug known to reverse the effects of an opioid overdose,was made available online in Louisiana, in the form of a nasal atomizer. It wasmade available on www.naloxoneexchange.com, a website by Script Health, aPublic Benefit Corporation.
Research on use of nasal devicesis expected to offer growth opportunities for market players. For instance,according to a study from the National Institute on Drug Abuse (NIDA), March2019, improvised nasal naloxone devices commonly used by first responders andthe general public deliver significantly less naloxone than regulator-approveddevices.
Major companies are also focusedon gaining contracts to enhance their market share. For instance, in May 2019,Kurve Technology, developer of ViaNase electronic atomizer, won the U.S.Department of Defense’s contract for testing a new formulation in combattingtraumatic brain injuries.
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