For the manufacture of hydrogels, cellulose derivatives such as (hydroxypropyl) methyl cellulose (HPMC), and methylcellulose (MC) are temperature-sensitive materials. Hydrogen bonds between polymers and water weakened at the LCST compared to interactions between polymers and water.
Since various bacteria and fungi found in air, water, and soil are able to produce cellulose-specific enzymes, cellulose and its derivatives are environmentally benign (i.e. celluloses). The two primary classes of Cellulose Derivative with varying physicochemical and mechanical properties are cellulose ethers and cellulose esters. The creation of dosage forms and healthcare items frequently uses these polymers. Due to the development of new derivatives and the discovery of novel uses for existing compounds by pharmaceutical researchers, cellulose and cellulose-based polymers have recently gained significant popularity in the pharmaceutical industries and are playing an increasingly significant role in this sector.